The SpaceX rocket was launched to the International Space Station (ISS), and the crew consists of American and Japanese astronauts, along with a Russian woman.
This is the first time in 20 years that a Russian cosmonaut has flown from the United States of America (USA), despite the tensions surrounding the war in Ukraine, reports AP.
They are said to be due to arrive at the space station today, 29 hours after their noon departure from NASA's Kennedy Space Center.
They are scheduled to stay at IS S until March.
The astronauts who took off are replacing the American-Italian crew that arrived at the station in April.
That flight was previously delayed by Hurricane Ian, which hit the US last Sunday.
"I hope that with this launch, we will brighten up the sky a little bit for everyone over Florida," said Koichi Wakata of the Japan Space Agency, who is making his fifth space flight.
It is noted that three new cosmonauts joined him in the five-month mission in space - Marine Colonel Nicole Mann, the first Indian woman to orbit the Earth, Navy Captain Josh Kashad and Anna Kikina from Russia.
It is part of the exchange of the Russian Space Agency for Frank Rubio from NASA, who two weeks ago launched himself from Kazakhstan to the space station with the Soyuz rocket.
The space agencies agreed over the summer to ensure a continued US and Russian presence on the IS S, despite the war in Ukraine, with the next crew exchange due in the spring.
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