Cambridge University Botanic Gardens lost its "Newton's Apple Tree" in Storm Eunice. Garden curator Samuel Brockington said the tree was planted in 1954 and stood at the entrance to Brookside Botanical Gardens for 68 years.
He said that the tree was a clone of the one that led Isaac Newton to discover the laws of gravity, writes the BBC.
The original tree from which the apple fell, which inspired Newton to devise his theory of gravity, is located at Woolsthorpe Manor in Grantham, Lincolnshire.
Although it fell in a storm in the 19th century, the tree survived and was propagated by grafting over the years.
Brockington said analysis showed that three trees in Cambridge, including the one in the botanical garden, were clones of Newton's original apple tree.
Although the fall of the tree in Friday's storm was a "sad loss", it was already "on the way" anyway because it had been attacked by a fungus.
The botanical garden is already in the process of obtaining a descendant of the "Newton apple tree" by grafting, Brockington said.
At least nine people have died, many from falling trees, in Storm Eunice, which has battered Ireland, Britain, Belgium and the Netherlands, while around 400.000 have been left without power in Britain.
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